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Article

Identification of residues that underpin interactions within the eukaryotic initiation factor (eIF2) 2B complex.

The Journal of biological chemistry - 9 Mar 2012

Wang Xuemin, Wortham Noel C, Liu Rui, Proud Christopher G

Abstract excerpt

Eukaryotic initiation factor 2B (eIF2B) plays a key role in protein synthesis and in its control. It comprises five different subunits, α-ε, of which eIF2Bε contains the catalytic domain. Formation of the complete complex is crucial for full activity and proper control of eIF2B. Mutations in the genes for eIF2B cause an often severe neurological disorder, "vanishing white matter." eIF2Bγ and eIF2Bε contain...

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Identifiers

PMID: 22238342
DOI: 10.1074/jbc.M111.331553
PMCID: PMC3318736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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