Article
Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 3 (MODY3) carrying a hepatocyte nuclear factor 1-alpha (HNF1A) mutation.
Stem cell research - 1 May 2018
Griscelli Frank, Ezanno Hélène, Soubeyrand Mathis, Feraud Olivier, Oudrhiri Noufissa, Bonnefond Amélie, Turhan Ali G, Froguel Philippe, Bennaceur-Griscelli Annelise
Abstract excerpt
Heterozygous non-synonymous (p.S142F) mutation in HNF1A leads to maturity-onset diabetes of the young (MODY) type 3, which is a subtype of dominant inherited young-onset non-autoimmune diabetes due to the defect of insulin secretion from pancreatic beta cells. We generated induced pluripotent stem cells (iPSCs) from a patient with HNF1A p.S142F mutation. Cells from this patient, which were reprogrammed by...
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