Article

The use of human pluripotent stem cells to model HNF1B-associated diabetes

2018-01-01

Abstract excerpt

Heterozygous mutations in the transcription factor, hepatocyte nuclear factor 1B (HNF1B), result in multisystem disease including diabetes due to beta-cell dysfunction and pancreatic hypoplasia. However, the mechanisms that underlie development of diabetes in HNF1B mutation carriers are still not fully understood due to lack of an appropriate model system. Human induced pluripotent stem cells (hiPSCs), which are c...

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Literature Corpus work: 5385dd04-53f0-5f69-809a-c2b3c73ae0ea
DOI: 10.17863/cam.32005

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