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Derivation of Human Induced Pluripotent Stem Cells from Patients with Maturity Onset Diabetes of the Young*

11 Jan 2013

Abstract excerpt

Maturity onset diabetes of the young (MODY) is an autosomal dominant disease. Despite extensive research, the mechanism by which a mutant MODY gene results in monogenic diabetes is not yet clear due to the inaccessibility of patient samples. Induced pluripotency and directed differentiation toward the pancreatic lineage are now viable and attractive methods to uncover the molecular mechanisms underlying MODY....

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PMID: 23306198
DOI: 10.1074/jbc.c112.428979

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Related research

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Derivation of Human Induced Pluripotent Stem Cells from Patients with Maturity Onset Diabetes of the Young*PMID 23306198Read ↗

Derivation and molecular characterization of pancreatic differentiated MODY1-iPSCsSemantic proximity Read ↗

Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 3 (MODY3) carrying a hepatocyte nuclear factor 1-alpha (HNF1A) mutation.Semantic proximity Read ↗

Modeling Maturity Onset Diabetes of the Young in Pluripotent Stem Cells: Challenges and Achievements.Semantic proximity Read ↗

HNF4A Haploinsufficiency in MODY1 Abrogates Liver and Pancreas Differentiation from Patient-Derived Induced Pluripotent Stem CellsSemantic proximity Read ↗

Generation of iPSC line ERCi004-A from human dermal fibroblasts of a patient with maturity-onset diabetes of the young type 3 caused by a heterozygous mutation in the <i>HNF1A</i> geneSemantic proximity Read ↗

Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 13 (MODY13) with a the potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) mutation.Semantic proximity Read ↗

The occurrence and development of induced pluripotent stem cellsSemantic proximity Read ↗

Generation of two human iPSC lines from patients with maturity-onset diabetes of the young type 2 (MODY2) and permanent neonatal diabetes due to mutations in the GCK gene.Semantic proximity Read ↗

Generation of an induced pluripotent stem cell line ERCi003-A derived from a patient with maturity-onset diabetes of the young type 10 caused by a heterozygous <i>INS</i> mutationSemantic proximity Read ↗

Pancreatic Beta Cell Differentiation From Human Pluripotent Stem CellsSemantic proximity Read ↗

Induced pluripotent stem cells as a model for diabetes investigationSemantic proximity Read ↗

Human Pluripotent Stem Cells to Model Islet Defects in Diabetes.Semantic proximity Read ↗

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