Article
[Mutations in the genes of the HNF-family cause maturity-onset diabetes of the young (MODY)].
Nihon rinsho. Japanese journal of clinical medicine - 1 Sept 1998
Takeda J
Abstract excerpt
Maturity-onset diabetes of the young (MODY) is a monogenic form of non-insulin-dependent diabetes mellitus (NIDDM) characterized by an early age of onset, often in childhood or adolescence and usually < 25 years of age, and autosomal dominant inheritance. Clinical characterization of patients wit...
Topics
- Adolescent
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Child
- Chromosome Mapping
- DNA-Binding Proteins
- Diabetes Mellitus, Type 2
- Genes, Dominant
- Hepatocyte Nuclear Factor 1
- Hepatocyte Nuclear Factor 1-alpha
- Hepatocyte Nuclear Factor 1-beta
- Hepatocyte Nuclear Factor 4
- Homeodomain Proteins
- Humans
- Insulin
- Insulin Secretion
- Islets of Langerhans
- Mutation
- Nuclear Proteins