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Article

Differentiation Therapy Targeting the β-Catenin/CBP Interaction in Pancreatic Cancer

29 Mar 2018

Abstract excerpt

Background: Although canonical Wnt signaling is known to promote tumorigenesis in pancreatic ductal adenocarcinoma (PDAC), a cancer driven principally by mutant K-Ras, the detailed molecular mechanisms by which the Wnt effector β-catenin regulates such tumorigenesis are largely unknown. We have previously demonstrated that β-catenin’s differential usage of the Kat3 transcriptional coactivator cyclic AMP-response...

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PMID: 29596326
DOI: 10.3390/cancers10040095

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