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Article

Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer.

Genome medicine - 20 Jul 2018

Kartha Vinay K, Alamoud Khalid A, Sadykov Khikmet, Nguyen Bach-Cuc, Laroche Fabrice, Feng Hui, Lee Jina, Pai Sara I, Varelas Xaralabos, Egloff Ann Marie, Snyder-Cappione Jennifer E, Belkina Anna C, Bais Manish V, Monti Stefano, Kukuruzinska Maria A

Abstract excerpt

BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy characterized by tumor heterogeneity, locoregional metastases, and resistance to existing treatments. Although a number of genomic and molecular alterations associated with HNSCC have been identified, they have had limited impact on the clinical management of this disease. To date, few targeted therapies are available for HNSCC,...

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Identifiers

PMID: 30029671
DOI: 10.1186/s13073-018-0569-7
PMCID: PMC6053793

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