Article

A Destabilizer of Both Wnt/β-Catenin and Ras/ERK Pathways Suppresses Cancer Stem Cell Activation in Colorectal Cancer

2022-03-10

Abstract excerpt

Cancer stem cells (CSCs) are a tumor cell subpopulation that drives tumor progression and metastasis, leading to poor overall survival of patients. In colorectal cancer (CRC), hyper-activation of Wnt/β-catenin signaling by mutation of both Adenomatous polyposis coli (APC) and K-Ras increases the size of the CSC population. We previously showed that the CPD0857 inactivates Wnt/β-catenin signaling by promo...

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Literature Corpus work: 2deecbd4-f353-5305-b187-7275be6912b0
DOI: 10.20944/preprints202203.0154.v1

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