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Article

A p300/GATA6 axis determines differentiation and Wnt dependency in pancreatic cancer models.

The Journal of clinical investigation - 15 Jun 2022

Zhong Zheng, Harmston Nathan, Wood Kris C, Madan Babita, Virshup David M

Abstract excerpt

Wnt signaling regulates the balance between stemness and differentiation in multiple tissues and in cancer. RNF43-mutant pancreatic cancers are dependent on Wnt production, and pharmacologic blockade of the pathway, e.g., by PORCN inhibitors, leads to tumor differentiation. However, primary resistance to these inhibitors has been observed. To elucidate potential mechanisms, we performed in vivo CRISPR screens in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35536676
DOI: 10.1172/JCI156305
PMCID: PMC9197518

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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