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Article

Stabilization of beta-catenin induces pancreas tumor formation.

Gastroenterology - 1 Oct 2008

Heiser Patrick W, Cano David A, Landsman Limor, Kim Grace E, Kench James G, Klimstra David S, Taketo Maketo M, Biankin Andrew V, Hebrok Matthias

Abstract excerpt

BACKGROUND & AIMS: beta-Catenin signaling within the canonical Wnt pathway is essential for pancreas development. However, the pathway is normally down-regulated in the adult organ. Increased cytoplasmic and nuclear localization of beta-catenin can be detected in nearly all human solid pseudopapillary neoplasms (SPN), a rare tumor with low malignant potential. Conversely, pancreatic ductal adenocarcinoma (PDA)...

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Share to beta Catenin
Share to Carcinoma, Papillary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Pancreatic Ducts

Share to Pancreatic Neoplasms

Share to Proto-Oncogene Proteins p21(ras)

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Source

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Identifiers

PMID: 18725219
DOI: 10.1053/j.gastro.2008.06.089
PMCID: PMC2613004

Genes

SPN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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