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Article

Regulation of β-catenin by t-DARPP in upper gastrointestinal cancer cells.

Molecular cancer - 29 Mar 2011

Vangamudi Bhavatarini, Zhu Shoumin, Soutto Mohammed, Belkhiri Abbes, El-Rifai Wael

Abstract excerpt

BACKGROUND: Truncated dopamine and cyclic-AMP-regulated phosphoprotein (t-DARPP) is frequently overexpressed in gastrointestinal malignancies. In this study, we examined the role of t-DARPP in regulating β-catenin. RESULTS: The pTopFlash construct that contains multiple TCF/LEF-binding sites was used as a measure of β-catenin/TCF transcription activity. Gastric (AGS, MKN28) and esophageal (FLO-1) adenocarcinoma...

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Identifiers

PMID: 21447180
DOI: 10.1186/1476-4598-10-32
PMCID: PMC3075216

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MYC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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