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Article

Reduced RNA turnover as a driver of cellular senescence.

Life science alliance - 1 Mar 2021

Mullani Nowsheen, Porozhan Yevheniia, Mangelinck Adèle, Rachez Christophe, Costallat Mickael, Batsché Eric, Goodhardt Michele, Cenci Giovanni, Mann Carl, Muchardt Christian

Abstract excerpt

Accumulation of senescent cells is an important contributor to chronic inflammation upon aging. The inflammatory phenotype of senescent cells was previously shown to be driven by cytoplasmic DNA. Here, we propose that cytoplasmic double-stranded RNA has a similar effect. We find that several cell types driven into senescence by different routes share an accumulation of long promoter RNAs and 3' gene extensions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33446491
DOI: 10.26508/lsa.202000809
PMCID: PMC7812316

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