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Article

Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence.

Nature communications - 19 Feb 2020

Zhao Bo, Liu Pingyu, Fukumoto Takeshi, Nacarelli Timothy, Fatkhutdinov Nail, Wu Shuai, Lin Jianhuang, Aird Katherine M, Tang Hsin-Yao, Liu Qin, Speicher David W, Zhang Rugang

Abstract excerpt

Cyclic cGMP-AMP synthase (cGAS) is a pattern recognition cytosolic DNA sensor that is essential for cellular senescence. cGAS promotes inflammatory senescence-associated secretory phenotype (SASP) through recognizing cytoplasmic chromatin during senescence. cGAS-mediated inflammation is essential for the antitumor effects of immune checkpoint blockade. However, the mechanism by which cGAS recognizes cytoplasmic...

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Identifiers

PMID: 32075966
DOI: 10.1038/s41467-020-14652-y
PMCID: PMC7031389

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