The role of the macrophage in sentinel responses in intestinal immunity.

doi:10.1097/MOG.0b013e32833d4b71

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Article

The role of the macrophage in sentinel responses in intestinal immunity.

Current opinion in gastroenterology - 1 Nov 2010

Sheikh Shehzad Z, Plevy Scott E

Abstract excerpt

PURPOSE OF REVIEW: The purpose of this review is to highlight macrophages as central mediators of intestinal immune homeostasis and inflammation. RECENT FINDINGS: We review recent developments elucidating distinct phenotypic adaptations in intestinal macrophages that determine their functional role in a microbe-rich environment. The involvement of intestinal macrophages in the pathogenesis of inflammatory bowel...

Topics

Animals
Homeostasis
Humans
Immunity, Innate
Immunity, Mucosal
Inflammatory Bowel Diseases
Intestinal Mucosa
Macrophage Activation
Macrophages
Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 20717022
DOI: 10.1097/MOG.0b013e32833d4b71
PMCID: PMC3214652

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