Article

M1 and M2 macrophages differentially regulate colonic crypt renewal

2022-07-14

Abstract excerpt

The colonic epithelium is the most rapidly renewing tissue in the body and is organized into a single cell layer of invaginations called crypts. Crypt renewal occurs through Lgr5+ gut stem cells situated at the crypt base, which divide, produce daughter cells that proliferate, migrate, differentiate into all the cells required for normal gut function (eg. Goblet cells, enterocytes), and are finally shed into the c...

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Literature Corpus work: 5a396482-118f-5a27-8b4a-4b5b394929c3
DOI: 10.1101/2022.07.13.499394

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