Article
Genetically determined variation in polyunsaturated fatty acid metabolism may result in different dietary requirements.
Nestle Nutrition workshop series. Paediatric programme - 1 Jan 2008
Koletzko Berthold, Demmelmair Hans, Schaeffer Linda, Illig Thomas, Heinrich Joachim
Abstract excerpt
Tissue availability of polyunsaturated fatty acids (PUFAs) is of major relevance for health, and it depends on both dietary intake and metabolic turnover. We found close associations between variants in the human genes of Delta5- and Delta6-desaturase, FADS1 and FADS2, and serum phospholipid contents of PUFAs and long-chain PUFAs (LCPUFAs). Polymorphisms and reconstructed haplotypes of FADS1 and the upstream...
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