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Article

Inhibiting YAP expression suppresses pancreatic cancer progression by disrupting tumor-stromal interactions

27 Mar 2018

Abstract excerpt

BACKGROUND: Hippo/YAP pathway is known to be important for development, growth and organogenesis, and dysregulation of this pathway leads to tumor progression. We and others find that YAP is up-regulated in pancreatic ductal adenocarcinoma (PDAC) and associated with worse prognosis of patients. Activated pancreatic stellate cells (PSCs) forming the components of microenvironment that enhance pancreatic cancer...

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PMID: 29587800
DOI: 10.1186/s13046-018-0740-4

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