Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

YAP overexpression promotes the epithelial-mesenchymal transition and chemoresistance in pancreatic cancer cells.

Molecular medicine reports - 1 Jan 2016

Yuan Yanli, Li Deyu, Li Haibo, Wang Liancai, Tian Guangjin, Dong Yadong

Abstract excerpt

The expression of Yes-associated protein (YAP) has been reported to be dysregulated in pancreatic cancer. However, its contributions to tumor formation and progression remain to be elucidated. The present study demonstrated that YAP overexpression promoted the epithelial‑mesenchymal transition (EMT) in a manner associated with pancreatic cancer invasion in vitro. RNA interference‑mediated silencing of YAP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Deoxycytidine
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gemcitabine

Share to Neoplasm Invasiveness

Share to Pancreatic Neoplasms

Share to Phosphoproteins

Share to Proto-Oncogene Proteins c-akt

Share to YAP-Signaling Proteins

Source

Identifiers

PMID: 26572166
DOI: 10.3892/mmr.2015.4550

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

YAP overexpression promotes the epithelial-mesenchymal transition and chemoresistance in pancreatic cancer cells.PMID 26572166Read ↗

Inhibiting YAP expression suppresses pancreatic cancer progression by disrupting tumor-stromal interactionsSemantic proximity Read ↗

YAP promotes the proliferation and migration of colorectal cancer cells through the Glut3/AMPK signaling pathwaySemantic proximity Read ↗

Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma.Semantic proximity Read ↗

A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transitionSemantic proximity Read ↗

Overexpression of GP73 promotes cell invasion, migration and metastasis by inducing epithelial-mesenchymal transition in pancreatic cancer.Semantic proximity Read ↗

microRNA signature for human pancreatic cancer invasion and metastasisSemantic proximity Read ↗

YAP1 oncogene is a context-specific driver for pancreatic ductal adenocarcinomaSemantic proximity Read ↗

CD133 facilitates epithelial-mesenchymal transition through interaction with the ERK pathway in pancreatic cancer metastasisSemantic proximity Read ↗

Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma.Semantic proximity Read ↗

Positive feedback regulation of lncRNA TPT1‐AS1 and ITGB3 promotes cell growth and metastasis in pancreatic cancerSemantic proximity Read ↗

Biological Significance of YAP/TAZ in Pancreatic Ductal AdenocarcinomaSemantic proximity Read ↗

MEKK3 Sustains EMT and Stemness in Pancreatic Cancer by Regulating YAP and TAZ Transcriptional ActivitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.