Article
Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion.
Cell reports - 25 Jan 2022
Murray Elizabeth R, Menezes Shinelle, Henry Jack C, Williams Josie L, Alba-Castellón Lorena, Baskaran Priththivika, Quétier Ivan, Desai Ami, Marshall Jacqueline J T, Rosewell Ian, Tatari Marianthi, Rajeeve Vinothini, Khan Faraz, Wang Jun, Kotantaki Panoraia, Tyler Eleanor J, Singh Namrata, Reader Claire S, Carter Edward P, Hodivala-Dilke Kairbaan, Grose Richard P, Kocher Hemant M, Gavara Nuria, Pearce Oliver, Cutillas Pedro, Marshall John F, Cameron Angus J M
Abstract excerpt
In pancreatic ductal adenocarcinoma (PDAC), differentiation of pancreatic stellate cells (PSCs) into myofibroblast-like cancer-associated fibroblasts (CAFs) can both promote and suppress tumor progression. Here, we show that the Rho effector protein kinase N2 (PKN2) is critical for PSC myofibroblast differentiation. Loss of PKN2 is associated with reduced PSC proliferation, contractility, and alpha-smooth muscle...
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