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Article

Unfolding of a ClC chloride transporter retains memory of its evolutionary history.

Nature chemical biology - 1 May 2018

Min Duyoung, Jefferson Robert E, Qi Yifei, Wang Jing Yang, Arbing Mark A, Im Wonpil, Bowie James U

Abstract excerpt

ClC chloride channels and transporters are important for chloride homeostasis in species from bacteria to human. Mutations in ClC proteins cause genetically inherited diseases, some of which are likely to involve folding defects. The ClC proteins present a challenging and unusual biological folding problem because they are large membrane proteins possessing a complex architecture, with many reentrant helices that...

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Identifiers

PMID: 29581582
DOI: 10.1038/s41589-018-0025-4
PMCID: PMC6038805

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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