Article

CFTR misfolds during native-centric simulations due to entropic penalties of native state formation

2018-06-18

Abstract excerpt

Cystic fibrosis (CF) is a common genetic disorder that affects approximately 70,000 people worldwide. It is caused by mutation-induced defects in synthesis, folding, processing, or function of the Cystic Fibrosis Transmembrane conductance Regulator protein (CFTR), a chloride-selective ion channel required for the proper functioning of secretory epithelia in tissues such as the lung, pancreas, and skin. The most co...

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Literature Corpus work: 7ea29938-8216-54b3-b0b1-0b01f7565e63
DOI: 10.1101/350074

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