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Article

Childhood adversity increases risk for nicotine dependence and interacts with α5 nicotinic acetylcholine receptor genotype specifically in males.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Feb 2012

Xie Pingxing, Kranzler Henry R, Zhang Huiping, Oslin David, Anton Raymond F, Farrer Lindsay A, Gelernter Joel

Abstract excerpt

The relative importance of specific genetic and environmental factors in regulating nicotine dependence (ND) risk, including the effects on specific forms of childhood adversity on smoking risk, have been understudied. Genome-wide association studies and rodent models have demonstrated that the α5 nicotinic acetylcholine receptor gene (CHRNA5) is important in regulating nicotine intake. Childhood adversity...

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Source

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Identifiers

PMID: 22012472
DOI: 10.1038/npp.2011.240
PMCID: PMC3260970

Genes

CHRNA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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