Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and antileukemic efficacy.

Blood - 31 May 2018

Nishii Rina, Moriyama Takaya, Janke Laura J, Yang Wenjian, Suiter Chase C, Lin Ting-Nien, Li Lie, Kihira Kentaro, Toyoda Hidemi, Hofmann Ute, Schwab Matthias, Takagi Masatoshi, Morio Tomohiro, Manabe Atsushi, Kham Shirley, Jiang Nan, Rabin Karen R, Kato Motohiro, Koh Katsuyoshi, Yeoh Allen Eng-Juh, Hori Hiroki, Yang Jun J

Abstract excerpt

Thiopurines (eg, 6-mercaptopurine [MP]) are highly efficacious antileukemic agents, but they are also associated with dose-limiting toxicities. Recent studies by us and others have identified inherited NUDT15 deficiency as a novel genetic cause of thiopurine toxicity, and there is a strong rationale for NUDT15-guided dose individualization to preemptively mitigate adverse effects of these drugs. Using CRISPR-Cas9...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimetabolites, Antineoplastic
Share to Drug Dosage Calculations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Evaluation, Preclinical

Share to Gene Editing

Share to Leukemia

Share to Mercaptopurine

Share to Phosphoric Diester Hydrolases

Share to Pyrophosphatases

Source

Open in PubMed Open full text

Identifiers

PMID: 29572377
DOI: 10.1182/blood-2017-11-815506
PMCID: PMC5981167

Genes

NUDT15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and antileukemic efficacy.PMID 29572377Read ↗

Additive effects of TPMT and NUDT15 on thiopurine toxicity in children with acute lymphoblastic leukemia across multiethnic populations.Semantic proximity Read ↗

The effects of inherited NUDT15 polymorphisms on thiopurine active metabolites in Japanese children with acute lymphoblastic leukemia.Semantic proximity Read ↗

NUDT15 Pharmacogenetics in Acute Lymphoblastic Leukemia: Synthesizing Progress for Personalized Thiopurine TherapySemantic proximity Read ↗

Novel variants in NUDT15 and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestry.Semantic proximity Read ↗

Impact of NUDT15 genetics on severe thiopurine-related hematotoxicity in patients with European ancestrySemantic proximity Read ↗

Severe Thiopurine-Induced Myelosuppression in a Pediatric Acute Lymphoblastic Leukemia Patient With the NUDT15 *1/*6 Genotype: A Brief Report.Semantic proximity Read ↗

DNA-thioguanine nucleotide as a treatment marker in acute lymphoblastic leukemia patients with NUDT15 variant genotypes.Semantic proximity Read ↗

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity.Semantic proximity Read ↗

Thiopurine-mediated impairment of hematopoietic stem and leukemia cells in Nudt15R138C knock-in mice.Semantic proximity Read ↗

NUDT15: A bench to bedside success story.Semantic proximity Read ↗

Comprehensive characterization of pharmacogenetic variants in TPMT and NUDT15 in children with acute lymphoblastic leukemiaSemantic proximity Read ↗

Emerging role of NUDT15 polymorphisms in 6-mercaptopurine metabolism and dose related toxicity in acute lymphoblastic leukaemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.