Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thiopurine-mediated impairment of hematopoietic stem and leukemia cells in Nudt15R138C knock-in mice.

Leukemia - 1 Mar 2020

Tatsumi Goichi, Kawahara Masahiro, Imai Takayuki, Nishishita-Asai Ai, Nishida Atsushi, Inatomi Osamu, Yokoyama Akihiko, Kakuta Yoichi, Kito Katsuyuki, Andoh Akira

Abstract excerpt

Thiopurines are widely used as antileukemia agents and immunosuppressants. Recent large-scale clinical studies revealed a strong association between the NUDT15 p.Arg139Cys (NUDT15R139C) polymorphism and severe thiopurine-induced leukocytopenia. We established knock-in mice harboring p.Arg138Cys (Nudt15R138C), which corresponds to the human polymorphism. A clinically relevant dose of mercaptopurine (MP) induced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair
Share to Flow Cytometry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knock-In Techniques

Share to Hematopoietic Stem Cells

Share to Leukemia

Share to Leukopenia

Share to Mercaptopurine

Share to Pyrophosphatases

Source

Identifiers

PMID: 31645647
DOI: 10.1038/s41375-019-0583-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thiopurine-mediated impairment of hematopoietic stem and leukemia cells in Nudt15R138C knock-in mice.PMID 31645647Read ↗

Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and antileukemic efficacy.Semantic proximity Read ↗

Additive effects of TPMT and NUDT15 on thiopurine toxicity in children with acute lymphoblastic leukemia across multiethnic populations.Semantic proximity Read ↗

NUDT15 Pharmacogenetics in Acute Lymphoblastic Leukemia: Synthesizing Progress for Personalized Thiopurine TherapySemantic proximity Read ↗

Novel variants in NUDT15 and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestry.Semantic proximity Read ↗

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity.Semantic proximity Read ↗

Single-Nucleotide Polymorphisms, c.415C > T (Arg139Cys) and c.416G > A (Arg139His), in the NUDT15 Gene Are Associated with Thiopurine-Induced Leukopenia.Semantic proximity Read ↗

A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia.Semantic proximity Read ↗

Impact of NUDT15 genetics on severe thiopurine-related hematotoxicity in patients with European ancestrySemantic proximity Read ↗

Homozygote CRIM1 variant is associated with thiopurine-induced neutropenia in leukemic patients with both wildtype NUDT15 and TPMTSemantic proximity Read ↗

An integrated triple approach - TPMT phenotype, NUDT-15 genotype, and therapeutic drug monitoring of thiopurine metabolites for optimal clinical efficacy: a case series.Semantic proximity Read ↗

Mercaptopurine induced myelosuppression in a child with a NUDT15 rs116855232 homozygous variant.Semantic proximity Read ↗

The effects of inherited NUDT15 polymorphisms on thiopurine active metabolites in Japanese children with acute lymphoblastic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.