Article

Causal network perturbation analysis identifies known and novel type-2 diabetes driver genes

2024-05-26

Abstract excerpt

The molecular pathogenesis of type 2 diabetes mellitus (T2DM) involves environmental and genetic factors that remain poorly understood. Increased insulin resistance leads to pancreatic β-islet cell exhaustion and failure, leading to more severe T2DM. As such, targeting β-cell dysfunction is an attractive pathway for T2DM treatment. Single-cell RNA sequencing can help identify differentially expressed genes (DEGs)...

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Literature Corpus work: 98a570b4-3cb9-538c-88f7-4466466f31fe
DOI: 10.1101/2024.05.22.595431

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