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Article

Enhanced basepair dynamics pre-disposes protein-assisted flips of key bases in DNA strand separation during transcription initiation.

Physical chemistry chemical physics : PCCP - 4 Apr 2018

Roy Neeladri Sekhar, Debnath Subrata, Chakraborty Abhijit, Chakraborty Prasenjit, Bera Indrani, Ghosh Raka, Ghoshal Nanda, Chakrabarti Saikat, Roy Siddhartha

Abstract excerpt

Localized separation of strands of duplex DNA is a necessary step in many DNA-dependent processes, including transcription and replication. Little is known about how these strand separations occur. The strand-separated E.coli RNA polymerase-promoter open-complex structure showed four bases of the non-template strand, the master base -11A, -7, -6 and +2, in a flipped state and inserted into protein pockets. To...

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PMID: 29565427
DOI: 10.1039/C8CP01119B

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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