Pds1/Esp1-dependent and -independent sister chromatid separation in mutants defective for protein phosphatase 2A.

doi:10.1073/pnas.0607856103

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Article

Pds1/Esp1-dependent and -independent sister chromatid separation in mutants defective for protein phosphatase 2A.

Proceedings of the National Academy of Sciences of the United States of America - 31 Oct 2006

Tang Xianying, Wang Yanchang

Abstract excerpt

Spindle disruption or DNA damage prevents sister chromatid separation through the activation of checkpoint pathways that inhibit anaphase entry by stabilizing the anaphase inhibitor Pds1. Mutation of CDC55, which encodes a B regulatory subunit of protein phosphatase 2A (PP2A), results in precocious sister chromatid separation when spindle is disrupted. Here we report that decreased Pds1 levels in Deltacdc55...

Topics

Anaphase
Anaphase-Promoting Complex-Cyclosome
Cell Cycle Proteins
Centromere
Chromatids
Chromosome Segregation
DNA Damage
DNA, Fungal
Endopeptidases
Gene Deletion
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nocodazole

Nuclear Proteins

Phosphoprotein Phosphatases

Protein Phosphatase 2

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Securin

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Identifiers

PMID: 17050679
DOI: 10.1073/pnas.0607856103
PMCID: PMC1637575

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Pds1/Esp1-dependent and -independent sister chromatid separation in mutants defective for protein phosphatase 2A.PMID 17050679Read ↗

An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast.Semantic proximity Read ↗

Cdk1 phosphorylation of Esp1/Separase functions with PP2A and Slk19 to regulate pericentric Cohesin and anaphase onset.Semantic proximity Read ↗

Pds5p is an essential chromosomal protein required for both sister chromatid cohesion and condensation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Pds1p is required for meiotic recombination and prophase I progression in Saccharomyces cerevisiae.Semantic proximity Read ↗

Coordination of chromatid separation and spindle elongation by antagonistic activities of mitotic and S-phase CDKs.Semantic proximity Read ↗

Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage.Semantic proximity Read ↗

Nuclear PP2A-Cdc55 prevents APC-Cdc20 activation during the spindle assembly checkpoint.Semantic proximity Read ↗

PP2A (Cdc)⁵⁵ is required for multiple events during meiosis I.Semantic proximity Read ↗

Genes involved in sister chromatid separation and segregation in the budding yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Protein phosphatase 2A (PP2A) promotes anaphase entry after DNA replication stress in budding yeast.Semantic proximity Read ↗

Faithful anaphase is ensured by Mis4, a sister chromatid cohesion molecule required in S phase and not destroyed in G1 phase.Semantic proximity Read ↗

The Pds1 anaphase inhibitor and Mec1 kinase define distinct checkpoints coupling S phase with mitosis in budding yeast.Semantic proximity Read ↗

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