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Article

Slk19p of Saccharomyces cerevisiae regulates anaphase spindle dynamics through two independent mechanisms.

Genetics - 1 Dec 2010

Havens Kyle A, Gardner Melissa K, Kamieniecki Rebecca J, Dresser Michael E, Dawson Dean S

Abstract excerpt

Slk19p is a member of the Cdc-14 early anaphase release (FEAR) pathway, a signaling network that is responsible for activation of the cell-cycle regulator Cdc14p in Saccharomyces cerevisiae. Disruption of the FEAR pathway results in defects in anaphase, including alterations in the assembly and behavior of the anaphase spindle. Many phenotypes of slk19Δ mutants are consistent with a loss of FEAR signaling, but...

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Identifiers

PMID: 20923975
DOI: 10.1534/genetics.110.123257
PMCID: PMC2998308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Slk19p of Saccharomyces cerevisiae regulates anaphase spindle dynamics through two independent mechanisms.PMID 20923975Read ↗

The FEAR protein Slk19 restricts Cdc14 phosphatase to the nucleus until the end of anaphase, regulating its participation in mitotic exit in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Cdc14 phosphatase and the FEAR network control meiotic spindle disassembly and chromosome segregation.Semantic proximity Read ↗

Slk19p is a centromere protein that functions to stabilize mitotic spindles.Semantic proximity Read ↗

Slk19-dependent mid-anaphase pause in kinesin-5-mutated cells.Semantic proximity Read ↗

Cdc14 inhibition by the spindle assembly checkpoint prevents unscheduled centrosome separation in budding yeast.Semantic proximity Read ↗

Regulation of Spo12 phosphorylation and its essential role in the FEAR network.Semantic proximity Read ↗

Cdk1 phosphorylation of Esp1/Separase functions with PP2A and Slk19 to regulate pericentric Cohesin and anaphase onset.Semantic proximity Read ↗

Regulation of mitotic spindle disassembly by an environmental stress-sensing pathway in budding yeast.Semantic proximity Read ↗

Slk19 clusters kinetochores and facilitates chromosome bipolar attachment.Semantic proximity Read ↗

Slk19p is necessary to prevent separation of sister chromatids in meiosis I.Semantic proximity Read ↗

The MEN mediates the effects of the spindle assembly checkpoint on Kar9-dependent spindle pole body inheritance in budding yeast.Semantic proximity Read ↗

FEAR but not MEN genes are required for exit from meiosis I.Semantic proximity Read ↗

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