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Article

Differential Transcriptional Regulation of Polymorphic p53 Codon 72 in Metabolic Pathways.

International journal of molecular sciences - 6 Oct 2021

Kim Bu-Yeo, Lee Seo-Young, Chung Sun-Ku

Abstract excerpt

p53 is a transcription factor that is activated under DNA damage stress and regulates the expression of proapoptotic genes including the expression of growth arrest genes to subsequently determine the fate of cells. To investigate the functional differences of polymorphic p53 codon 72, we constructed isogenic lines encoding each polymorphic p53 codon 72 based on induced pluripotent stem cells, which can...

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Identifiers

PMID: 34639134
DOI: 10.3390/ijms221910793
PMCID: PMC8509680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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