Article
Mouse models for the p53 R72P polymorphism mimic human phenotypes.
Cancer research - 15 Jul 2010
Zhu Feng, Dollé Martijn E T, Berton Thomas R, Kuiper Raoul V, Capps Carrie, Espejo Alexsandra, McArthur Mark J, Bedford Mark T, van Steeg Harry, de Vries Annemieke, Johnson David G
Abstract excerpt
The p53 tumor suppressor gene contains a common single nucleotide polymorphism (SNP) that results in either an arginine or proline at position 72 of the p53 protein. This polymorphism affects the apoptotic activity of p53 but the mechanistic basis and physiologic relevance of this phenotypic difference remain unclear. Here, we describe the development of mouse models for the p53 R72P SNP using two different...
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