Article
The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction.
Cell reports - 15 Mar 2016
Kung Che-Pei, Leu Julia I-Ju, Basu Subhasree, Khaku Sakina, Anokye-Danso Frederick, Liu Qin, George Donna L, Ahima Rexford S, Murphy Maureen E
Abstract excerpt
p53 is well known for its tumor suppressor role, but this protein also has a poorly understood role in the regulation of metabolism. Human studies have implicated a common polymorphism at codon 72 of p53 in diabetic and pre-diabetic phenotypes. To understand this role, we utilized a humanized mouse model of the p53 codon 72 variants and monitored these mice following challenge with a high-fat diet (HFD). Mice...
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