Article
Hierarchical organization of multi-site phosphorylation at the CXCR4 C terminus.
PloS one - 1 Jan 2013
Mueller Wiebke, Schütz Dagmar, Nagel Falko, Schulz Stefan, Stumm Ralf
Abstract excerpt
The chemokine receptor CXCR4 regulates cell migration during ontogenesis and disease states including cancer and inflammation. Upon stimulation by the endogenous ligand CXCL12, CXCR4 becomes phosphorylated at multiple sites in its C-terminal domain. Mutations in the CXCR4 gene affecting C-terminal phosphorylation sites are a hallmark of WHIM syndrome, a genetic disorder characterized by a gain-of-CXCR4-function....
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