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Article

Differential desensitization, receptor phosphorylation, beta-arrestin recruitment, and ERK1/2 activation by the two endogenous ligands for the CC chemokine receptor 7.

The Journal of biological chemistry - 28 May 2004

Kohout Trudy A, Nicholas Shelby L, Perry Stephen J, Reinhart Greg, Junger Sachiko, Struthers R Scott

Abstract excerpt

Many members of the chemokine receptor family of G protein-coupled receptors utilize multiple endogenous ligands. However, differences between the signaling properties of multiple chemokines through a single receptor have yet to be well characterized. In this study we investigated the early signaling events of CCR7 initiated by its two endogenous ligands, CCL19 and CCL21. Both CCL19 and CCL21 induce G protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15054093
DOI: 10.1074/jbc.M402125200

Genes

CCL19
CCR7
CCL21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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