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Article

Cortisol Co-Secretion and Clinical Usefulness of ACTH Stimulation Test in Primary Aldosteronism: A Systematic Review and Biases in Epidemiological Studies.

Frontiers in endocrinology - 1 Jan 2021

Inoue Kosuke, Kitamoto Takumi, Tsurutani Yuya, Saito Jun, Omura Masao, Nishikawa Tetsuo

Abstract excerpt

The hypothalamus-pituitary-adrenal (HPA) axis plays an important role in primary aldosteronism. Aldosterone biosynthesis is regulated not only by angiotensin II in the renin-angiotensin-aldosterone system, but also by adrenocorticotropic hormone (ACTH), one of the key components of the HPA axis. Although previous studies have reported cortisol cosecretion in primary aldosteronism, particularly...

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Identifiers

PMID: 33796078
DOI: 10.3389/fendo.2021.645488
PMCID: PMC8008473

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