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Article

Polygenic risk score of SERPINA6/SERPINA1 associates with diurnal and stress-induced HPA axis activity in children.

Psychoneuroendocrinology - 1 Jul 2018

Utge Siddheshwar, Räikkönen Katri, Kajantie Eero, Lipsanen Jari, Andersson Sture, Strandberg Timo, Reynolds Rebecca M, Eriksson Johan G, Lahti Jari

Abstract excerpt

PURPOSE: Corticosteroid-binding globulin (CBG) transports glucocorticoids in blood. Variation in genes SERPINA6 encoding for CBG, SERPINA2 and SERPINA1 (serpin family A member 6, 2, and 1) have been shown to influence morning plasma cortisol and CBG in adults. However, association of this genetic variation with diurnal and stress-induced salivary cortisol remain unknown. This study aims to investigate the effect...

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Identifiers

PMID: 29679879
DOI: 10.1016/j.psyneuen.2018.04.009

Genes

SERPINA6
SERPINA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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