Article
Interleukin-6 is essential for glomerular immunoglobulin A deposition and the development of renal pathology in Cd37-deficient mice.
Kidney international - 1 Jun 2018
Rops Angelique L W M M, Jansen Erik, van der Schaaf Alie, Pieterse Elmar, Rother Nils, Hofstra Julia, Dijkman Henry B P M, van de Logt Anne-Els, Wetzels Jack, van der Vlag Johan, van Spriel Annemiek B
Abstract excerpt
Immunoglobulin A (IgA) nephropathy (IgAN), the most common glomerulonephritis worldwide, is characterized by IgA depositions in the kidney. Deficiency of CD37, a leukocyte-specific tetraspanin, leads to spontaneous development of renal pathology resembling IgAN. However, the underlying molecular mechanism has not been resolved. Here we found that CD37 expression on B cells of patients with IgAN was significantly...
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