Granulin Exacerbates Lupus Nephritis via Enhancing Macrophage M2b Polarization

Abstract excerpt

BACKGROUND AND AIMS: Lupus nephritis (LN), with considerable morbidity and mortality, is one of the most severe manifestations of systemic lupus erythematosus (SLE). Yet, the pathogenic mechanisms of LN have not been clearly elucidated, and efficient therapies are still in great need. Granulin (GRN), a multifunctional protein linked to inflammatory diseases, has recently been reported to correlate with the...

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