Article
Knockout of the interleukin-36 receptor protects against renal ischemia-reperfusion injury by reduction of proinflammatory cytokines.
Kidney international - 1 Mar 2018
Nishikawa Hirofumi, Taniguchi Yoshinori, Matsumoto Tatsuki, Arima Naoki, Masaki Mamoru, Shimamura Yoshiko, Inoue Kosuke, Horino Taro, Fujimoto Shimpei, Ohko Kentaro, Komatsu Toshihiro, Udaka Keiko, Sano Shigetoshi, Terada Yoshio
Abstract excerpt
IL-36, a newly named member of the IL-1 cytokine family, includes 3 isoforms, IL-36α, IL-36β, and IL-36γ, all of which bind to a heterodimer containing the IL-36 receptor (IL-36R). Little is known about the role of the IL-36 axis in acute kidney injury (AKI) pathogenesis. Therefore, we evaluated IL-36 function in the bilateral renal ischemia-reperfusion injury model of AKI using IL-36R knockout and wild-type...
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