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Article

Age-related pathology after adenoviral overexpression of the leucine-rich repeat kinase 2 in the mouse striatum.

Neurobiology of aging - 1 Jun 2018

Kritzinger Astrid, Ferger Boris, Gillardon Frank, Stierstorfer Birgit, Birk Gerald, Kochanek Stefan, Ciossek Thomas

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 (LRRK2) age-dependently cause Parkinson's disease and are associated with several inflammatory diseases. So far, the potential role of LRRK2 expression in glial cells as mediators of neuroinflammation and the influence of aging have not been investigated in viral vector-based LRRK2 animal models. In this study, we compared the effect of striatal injection of high-capacity...

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Identifiers

PMID: 29550548
DOI: 10.1016/j.neurobiolaging.2018.02.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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