Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Slc6a3-dependent expression of a CAPS-associated Nlrp3 allele results in progressive behavioral abnormalities and neuroinflammation in aging mice.

Journal of neuroinflammation - 17 Jul 2020

von Herrmann Katharine M, Anderson Faith L, Martinez Eileen M, Young Alison L, Havrda Matthew C

Abstract excerpt

BACKGROUND: An association between neuroinflammation and age-related neurologic disorders has been established but the molecular mechanisms and cell types involved have not been thoroughly characterized. Activity of the proinflammatory NLRP3 inflammasome is implicated in Alzheimer's and Parkinson's disease and our recent studies in patients suggest that dopaminergic neurons within the degenerating mesencephalon...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Cryopyrin-Associated Periodic Syndromes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopamine Plasma Membrane Transport Proteins

Share to Dopaminergic Neurons

Share to Inflammation

Share to Inflammation Mediators

Share to Motor Activity

Share to NLR Family, Pyrin Domain-Containing 3 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 32680528
DOI: 10.1186/s12974-020-01866-6
PMCID: PMC7368774

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Slc6a3-dependent expression of a CAPS-associated Nlrp3 allele results in progressive behavioral abnormalities and neuroinflammation in aging mice.PMID 32680528Read ↗

Slc6a3-dependent expression of a CAPS-associated Nlrp3 allele results in progressive behavioral abnormalities and neuroinflammation in aging miceSemantic proximity Read ↗

Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.Semantic proximity Read ↗

Inflammasome mediated neuronal-microglial crosstalk: a therapeutic substrate for the familial <i>C9orf72</i> variant of the frontotemporal dementia/amyotrophic lateral sclerosisSemantic proximity Read ↗

Inflammasome mediated neuronal-microglial crosstalk: a therapeutic substrate of the familial C9orf72 variant of frontotemporal dementia/amyotrophic lateral sclerosisSemantic proximity Read ↗

Mice humanized by syntenic replacement with full-length NLRP3 disease-associated variants model the clinical cryopyrinopathy continuum.Semantic proximity Read ↗

The discovery of NLRP3 and its function in cryopyrin‐associated periodic syndromes and innate immunitySemantic proximity Read ↗

A Knock-In Mouse Model of Cryopyrin-Associated Periodic Syndromes.Semantic proximity Read ↗

Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies.Semantic proximity Read ↗

NLRP3 leucine-rich repeats control induced and spontaneous inflammasome activation in cryopyrin-associated periodic syndromeSemantic proximity Read ↗

Pharmacologic NLRP3 Inhibition Modulates Parkinson’s Disease-Associated Microglial Transcriptomic Signatures and Mitigates α-Synuclein–Triggered NeurodegenerationSemantic proximity Read ↗

Progranulin is increased during prodromal pathology in LRRK2 G2019S mice.Semantic proximity Read ↗

Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALSSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.