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Article

Aging reduces glial uptake and promotes extracellular accumulation of Aβ from a lentiviral vector

15 Aug 2014

Abstract excerpt

We used a lentiviral system for expressing secreted human Aβ in the brains of young and old APOE knock-in mice. This system allowed us to examine Aβ metabolism in vivo, and test the effects of both aging and APOE genotype, two of the strongest risk factors for Alzheimer's disease. We injected the Aβ1-42 lentivirus into the motor cortex of young (2 month old) and old (20-22 month old) APOE3 and APOE4 mice. After 2...

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PMID: 25177293
DOI: 10.3389/fnagi.2014.00210

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