Article
An international meta-analysis confirms the association of BNC2 with adolescent idiopathic scoliosis.
Scientific reports - 16 Mar 2018
Ogura Yoji, Takeda Kazuki, Kou Ikuyo, Khanshour Anas, Grauers Anna, Zhou Hang, Liu Gang, Fan Yan-Hui, Zhou Taifeng, Wu Zhihong, Takahashi Yohei, Matsumoto Morio, Einarsdottir Elisabet, Kere Juha, Huang Dongsheng, Qiu Guixing, Xu Leilei, Qiu Yong, Wise Carol A, Song You-Qiang, Wu Nan, Su Peiqiang, Gerdhem Paul, Watanabe Kota, Ikegawa Shiro
Abstract excerpt
Adolescent idiopathic scoliosis (AIS) is a common spinal deformity with the prevalence of approximately 3%. We previously conducted a genome-wide association study (GWAS) using a Japanese cohort and identified a novel locus on chromosome 9p22.2. However, a replication study using multi-population cohorts has not been conducted. To confirm the association of 9p22.2 locus with AIS in multi-ethnic populations, we...
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