Article
[Genome-wide association study for adolescent idiopathic scoliosis].
Clinical calcium - 1 Apr 2016
Ogura Yoji, Kou Ikuyo, Scoliosis Japan, Matsumoto Morio, Watanabe Kota, Ikegawa Shiro
Abstract excerpt
Adolescent idiopathic scoliosis(AIS)is a polygenic disease. Genome-wide association studies(GWASs)have been performed for a lot of polygenic diseases. For AIS, we conducted GWAS and identified the first AIS locus near LBX1. After the discovery, we have extended our study by increasing the numbers of subjects and SNPs. In total, our Japanese GWAS has identified four susceptibility genes. GWASs for AIS have also...
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