Identification of a susceptibility locus for severe adolescent idiopathic scoliosis on chromosome 17q24.3.

doi:10.1371/journal.pone.0072802

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Article

Identification of a susceptibility locus for severe adolescent idiopathic scoliosis on chromosome 17q24.3.

PloS one - 1 Jan 2013

Miyake Atsushi, Kou Ikuyo, Takahashi Yohei, Johnson Todd A, Ogura Yoji, Dai Jin, Qiu Xusheng, Takahashi Atsushi, Jiang Hua, Yan Huang, Kono Katsuki, Kawakami Noriaki, Uno Koki, Ito Manabu, Minami Shohei, Yanagida Haruhisa, Taneichi Hiroshi, Hosono Naoya, Tsuji Taichi, Suzuki Teppei, Sudo Hideki, Kotani Toshiaki, Yonezawa Ikuho, Kubo Michiaki, Tsunoda Tatsuhiko, Watanabe Kota, Chiba Kazuhiro, Toyama Yoshiaki, Qiu Yong, Matsumoto Morio, Ikegawa Shiro

Abstract excerpt

Adolescent idiopathic scoliosis (AIS) is the most common spinal deformity, affecting around 2% of adolescents worldwide. Genetic factors play an important role in its etiology. Using a genome-wide association study (GWAS), we recently identified novel AIS susceptibility loci on chromosomes 10q24.31 and 6q24.1. To identify more AIS susceptibility loci relating to its severity and progression, we performed GWAS by...

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Identifiers

PMID: 24023777
DOI: 10.1371/journal.pone.0072802
PMCID: PMC3762929

Genes

KCNJ2
SOX9

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