Article
Genome-wide association study identifies new susceptibility loci for adolescent idiopathic scoliosis in Chinese girls.
Nature communications - 22 Sept 2015
Zhu Zezhang, Tang Nelson Leung-Sang, Xu Leilei, Qin Xiaodong, Mao Saihu, Song Yueming, Liu Limin, Li Fangcai, Liu Peng, Yi Long, Chang Jiang, Jiang Long, Ng Bobby Kin-Wah, Shi Benlong, Zhang Wen, Qiao Jun, Sun Xu, Qiu Xusheng, Wang Zhou, Wang Fei, Xie Dingding, Chen Ling, Chen Zhonghui, Jin Mengran, Han Xiao, Hu Zongshan, Zhang Zhen, Liu Zhen, Zhu Feng, Qian Bang-Ping, Yu Yang, Wang Bing, Lee K M, Lee Wayne Y W, Lam T P, Qiu Yong, Cheng Jack Chun-Yiu
Abstract excerpt
Adolescent idiopathic scoliosis (AIS) is a structural deformity of the spine affecting millions of children. As a complex disease, the genetic aetiology of AIS remains obscure. Here we report the results of a four-stage genome-wide association study (GWAS) conducted in a sample of 4,317 AIS patients and 6,016 controls. Overall, we identify three new susceptibility loci at 1p36.32 near AJAP1 (rs241215,...
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