Article
Genome-wide association study identifies novel susceptible loci and highlights Wnt/beta-catenin pathway in the development of adolescent idiopathic scoliosis.
Human molecular genetics - 15 Apr 2017
Zhu Zezhang, Xu Leilei, Leung-Sang Tang Nelson, Qin Xiaodong, Feng Zhenhua, Sun Weixiang, Zhu Weiguo, Shi Benlong, Liu Peng, Mao Saihu, Qiao Jun, Liu Zhen, Sun Xu, Li Fangcai, Chun-Yiu Cheng Jack, Qiu Yong
Abstract excerpt
The genetic architecture of adolescent idiopathic scoliosis (AIS) remains poorly understood. Here we present the result of a 4-stage genome-wide association study composed of 5,953 AIS patients and 8,137 controls. Overall, we identified three novel susceptible loci including rs7593846 at 2p14 near MEIS1 (Pcombined = 1.19 × 10-13, OR = 1.21, 95% CI = 1.10-1.32), rs7633294 at 3p14.1 near MAGI1 (Pcombined = 1.85 ×...
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