Article

Whole Genome Sequencing in Adolescent Idiopathic Scoliosis Cohort Indicates Polygenic Disease Involving Multiple Biological Pathways

2025-01-28

Abstract excerpt

<h4>ABSTRACT</h4> Adolescent idiopathic scoliosis (AIS) is the most common nondegenerative spinal abnormality. Research indicates a strong correlation between genetics and AIS, with heritability estimates of 87.5%. However, the rarity of shared causative genes among patients, and the difficulty of replication between studies suggest that AIS is a highly complex polygenic disease. In this study, we utilized whole-g...

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Literature Corpus work: c7d74b8e-d755-536a-a763-f47ef6effcd9
DOI: 10.1101/2025.01.23.25321049

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