Article
A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis.
Scientific reports - 1 Aug 2018
Kou Ikuyo, Watanabe Kota, Takahashi Yohei, Momozawa Yukihide, Khanshour Anas, Grauers Anna, Zhou Hang, Liu Gang, Fan Yan-Hui, Takeda Kazuki, Ogura Yoji, Zhou Taifeng, Iwasaki Yusuke, Kubo Michiaki, Wu Zhihong, Matsumoto Morio, Einarsdottir Elisabet, Kere Juha, Huang Dongsheng, Qiu Guixing, Qiu Yong, Wise Carol A, Song You-Qiang, Wu Nan, Su Peiqiang, Gerdhem Paul, Ikegawa Shiro
Abstract excerpt
Adolescent idiopathic scoliosis (AIS) is the most common type of spinal deformity and has a significant genetic background. Genome-wide association studies (GWASs) identified several susceptibility loci associated with AIS. Among them is a locus on chromosome 6q24.1 that we identified by a GWAS in a Japanese cohort. The locus is represented by rs6570507 located within GPR126. To ensure the association of...
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