Article
Genome-wide association studies of adolescent idiopathic scoliosis suggest candidate susceptibility genes.
Human molecular genetics - 1 Apr 2011
Sharma Swarkar, Gao Xiaochong, Londono Douglas, Devroy Shonn E, Mauldin Kristen N, Frankel Jessica T, Brandon January M, Zhang Dongping, Li Quan-Zhen, Dobbs Matthew B, Gurnett Christina A, Grant Struan F A, Hakonarson Hakon, Dormans John P, Herring John A, Gordon Derek, Wise Carol A
Abstract excerpt
Adolescent idiopathic scoliosis (AIS) is an unexplained and common spinal deformity seen in otherwise healthy children. Its pathophysiology is poorly understood despite intensive investigation. Although genetic underpinnings are clear, replicated susceptibility loci that could provide insight into etiology have not been forthcoming. To address these issues, we performed genome-wide association studies (GWAS) of...
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