Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy

Abstract excerpt

// Estefania Martino-Echarri 1 , Beric R. Henderson 1,* and Mariana G. Brocardo 1,* 1 Centre for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead, New South Wales, Australia * These authors contributed equally to this work Correspondence: Mariana G. Brocardo, email: // Keywords : 5-fluorouracil, APC, DNA replication checkpoint, Chk1 inhibitors, colon cancer...

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